Korean J Neuromuscul Disord Search

CLOSE


Korean Journal of Neuromuscular Disorders 2009;1(1):45-50.
The Anatomy and Neuroimmmunology of Neuromuscular Junction
Young-Chul Choi
Departments of Neurology, Yonsei University College of Medicine, Seoul, Korea
신경근육접합의 구조와 신경면역학
최영철
연세대학교 의과대학 신경과학교실
Abstract
The Neuromuscular junction (NMJ) is the specialized structure between motor nerves and skeletal muscle, which consisted of presynaptic membrane, synaptic cleft and postsynaptic membrane. This complex structures converts nerve action potentials into muscle contraction. It is a target of a various neuroimmunologic disorders due to vulnerable to antibody-mediated attack. The main autoimmune disorders of NMJ are myasthenia gravis (MG)and Lambert-Eaton myasthenic syndrome (LEMS). The understanding of the immunological basis of MG and LEMS has improved in the recent years. This review provides the outline of the anatomy and physiology of the NMJ. It also focuses on recent advance of immunopathogenesis of NMJ disorder.


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine
170, Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, 10380 Korea
Tel: +82-31-910-7929    Fax: +82-31-910-7368    E-mail: joongyangcho@gmail.com                

Copyright © 2022 by Korean Society of Neuromuscular Disorders.

Developed in M2PI

Close layer
prev next