Immunotherapy for Autoimmune Neuromuscular Diseases

Kim, Nam-Hee

Review article

Korean Journal of Neuromuscular Disorders 2015;7(2):64-73.

Nam-Hee Kim

Department of Neurology, Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea

자가면역 신경근육질환의 면역치료

김남희

동국대학교 의과대학 일산병원 신경과

Abstract

Rational targets for autoimmune neuromuscular disease have been identified with the progress of our understanding of the cellular and molecular process underlying autoimmune neuromuscular disease. Although antigen-specific immunotherapy is not available, effective immunotherapy for most autoimmune disorders is provided with old and new immunomodulatory treatments, alone or in combination. The achievements of more specific yet largely experimental therapeutic tools need to be tested in the human diseases. Here we review the principles and targets of immunotherapy for autoimmune neuromuscular disorders, applications, and practical guidelines, and give an outlook on future developments.