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Korean Journal of Neuromuscular Disorders 2015;7(1):33-37.
A Correlation between Plasma Homocysteine and Polyneuropathy in Parkinson’s Disease
In-Uk Song, Young-Do Kim, Dushin Jeong, MPH
aDepartment of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon; bDepartment of Neurology and Clinical Epidemiology, College of Medicine Soonchunhyang University, Cheonan, Korea
Recently, polyneuropathy has been been described in higher proportions for patients with Parkinson’s disease (PD) than in normal population. This finding was hypothesized to be related to the elevation of plasma homocysteine, following the management of PD with levodopa. We conducted this study to clarify the clinical value of elevated plasma homocysteine in PD patients for their relation to polyneuropathy. Methods: A total of 37 PD patients without neuropathy (PD control) and 41 PD patients with polyneuropathy (PDP), who were recruited for this study, were compared with age and sex matched 48 healthy controls. All PD patients performed electrophysiological tests, including nerve conduction study, to diagnose polyneuropathy. Plasma homocysteine levels were measured in all subjects and compared between each groups. Results: The homocysteine of PDP showed higher homocysteine level than those of PD control and healthy controls. However, there was no significant difference in homocysteine levels between PD control and healthy controls. In each group of PD control and PDP, there were no intercorrelations between daily levodopa dose, duration of PD symptoms and PD treatment or motor severity with homocysteine levels. Conclusions: We could cautiously assume that plasma homocysteine level may be related with the involvement of peripheral nerve of PD patients in this study. The pathophysiologic role of homocysteine and the relationship between plasma homocysteine level and levodopa in PDP need to be confirmed.
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