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Korean J Neuromuscul Disord > Volume 12(2); 2020 > Article
Korean Journal of Neuromuscular Disorders 2020;12(2):36-38.
DOI: https://doi.org/10.46518/kjnmd.2020.12.2.36    Published online December 31, 2020.
A Guillain-Barré Syndrome with Anti-GQ1b and Anti-GT1a Antibodies Positivity Manifesting with Acute Bulbar Palsy and Subsequent Delayed Ophthalmoplegia
Seonmin Yoon1, Jong Seo Bae1, Byeol-A Yoon2, Jong Kuk Kim2, Yerim Kim1, Sang-Hwa Lee3
1Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
2Department of Neurology, Dong-A University Hospital, Busan, Korea
3Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea
연수마비로 시작하여 지연성 안근마비가 순차적으로 발생한 항GQ1b와 항GT1a 양성 길랭-바레 증후군
윤선민1, 배종석1, 윤별아2, 김종국2, 김예림1, 이상화3
1한림대학교 의과대학 강동성심병원 신경과
2동아대학교병원 신경과
3한림대학교 의과대학 춘천성심병원 신경과
Correspondence:  Sang-Hwa Lee, Tel: +82-33-240-5255, Fax: +82-33-241-8063, 
Email: bleulsh@naver.com
Received: 4 February 2020   • Revised: 9 April 2020   • Accepted: 23 December 2020
Abstract
In Guillain-Barré syndrome (GBS) and its variant, anti-GQ1b antibody has a pathogenic role for ophthalmoplegia. In addition, anti-GT1a antibody is related with lower cranial nerve involvement. This report describes a 60-year-old male patient with GBS manifesting with initially isolated dysphagia and subsequently developed ophthalmoplegia. Both immunoglobulin G type anti-GQ1b and anti-GT1a antibodies were detected in the patient’s serum. A mechanism regarding subsequent involvement of respective cranial nerves remains to be elucidated.
Key Words: Gangliosides, Bulbar palsy, Ophthalmoplegia
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