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Korean Journal of Neuromuscular Disorders 2019;11(2):55-58.
Published online February 19, 2020.
Severe Hyponatremia during Acyclovir Treatment in Shingles.
Jiyong Shin, Miyeon Kim, Jeong Rae Yoo, Sa Yoon Kang, Jung Hwan Oh
1Department of Neurology, Jeju National University School of Medicine, Jeju, Korea. oh.junghwan77@gmail.com
2Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
Abstract
Acyclovir is effective in treating the herpes virus infection, especially chickenpox and shingles. Hyponatremia caused by acyclovir has been rarely reported. We present a shingles patient with symptomatic hyponatremia that was presumably caused by acyclovir affecting the hypothalamus or posterior pituitary gland. This case demonstrates that the serum electrolyte levels should be checked regularly and careful observation of symptoms such as nausea, convulsions, or mentality change is necessary in patients treated with acyclovir.
Key Words: Acyclovir, Hyponatremia, Herpes zoster, Inappropriate ADH syndrome
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